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1. Fast solid phase peptide synthesis techniques
Fast solid phase peptide synthesis techniques was developed by amecrican scienst
Christina. Hood et.al. by this method, peptides synthesis is accelorated by above
10 times and the peptides purity also is improved compared to the traditional method.
Now the course of coupling, washing and deprotecting one amino acid costs only 14-17min.
for example, Ab(1-42)amyloid peptide was synthesized in 11.6h by PTI 12 mutiple
synthesizer symphony, and the purity reached about 70%. This technique is really
fast and bulky for synthesis and has a big advance on peptide drug research.
2. Microwave solid-phase peptide synthesis
Research Liberty Microwave Peptide
Synthesizer level is the world's microwave chemistry founders - the United States
developed a professional CEM peptide synthesizer, is currently the fastest growing
market share, recognized as the world's first research-level automatic peptide synthesizer.
Liberty peptide synthesizer breakthrough
has been plagued traditional solid-phase peptide synthesis methods as well as conventional
synthesizer technology bottleneck, that is, the process of polypeptide chain reaction
polymerization phenomenon. Liberty is the innovative use of
electromagnetic field focusing ring, multi-peptide chain in this circular under
the influence of electromagnetic field focusing stretching can be fully opened,
which can be very efficient for peptide synthesis process in a series of reactions,
such as deprotection, coupling, as well as cutting reaction.
Peptide synthesis of multi-hour time
from the past to rewrite the history unit in minutes as a unit at the same time,
realize the past is hard to imagine the difficulties of long peptides and peptide
synthesis.
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